Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
نویسندگان
چکیده
منابع مشابه
Metabolic endotoxemia initiates obesity and insulin resistance.
Diabetes and obesity are two metabolic diseases characterized by insulin resistance and a low-grade inflammation. Seeking an inflammatory factor causative of the onset of insulin resistance, obesity, and diabetes, we have identified bacterial lipopolysaccharide (LPS) as a triggering factor. We found that normal endotoxemia increased or decreased during the fed or fasted state, respectively, on ...
متن کاملComment on: Cani et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance: Diabetes 56:1761-1772.
The recent article by Cani et al. (1) interests us very much. We have reported that obesity and periodontitis were associated for the first time in 1998 (2). Further study revealed that hepatic impairment was more strongly associated with periodontitis than obesity indexes (3). Our results showed that periodontitis increased with elevated serum levels of aspartate aminotransferase, alanine amin...
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There has been a remarkable increase in interest during the past two decades in the relation between cardiovascular risk factors in children and the development of arteriosclerotic cardiovascular disease (ASCVD) and type 2 diabetes in adulthood. Initial studies concentrated on individual factors such as lipids and blood pressure. However, as research in this areahas evolvedandpediatricianshave ...
متن کاملObesity genes and insulin resistance.
PURPOSE OF REVIEW The exploding prevalence of insulin resistance and Type 2 diabetes (T2D) linked to obesity has become an alarming public health concern. Worldwide, approximately 171 million people suffer from obesity-induced diabetes and public health authorities expect this situation to deteriorate rapidly. An interesting clinical population of 'metabolically healthy but obese' (MHO) cases i...
متن کامل[Obesity, adipogenesis and insulin resistance].
Insulin resistance precedes the development of type 2 diabetes mellitus and is also a common denominator in the so-called metabolic syndrome. Although the cause of insulin resistance has not been fully elucidated, it seems clear that lifestyle changes, including little physical exercise and constant access to food, particularly in developed and economically emergent countries, as well as geneti...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2007
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db06-1491